解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:The liver is an immunologic privileged organ; liver allografts are accepted across major histocompatibility complex barriers in many species. However, hepatocyte transplants are acutely rejected, suggesting a role for liver nonparenchymal cells in regulating the immunoresponse. We have shown potent immunoreg...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318294caae
更新日期:2013-07-15 00:00:00
abstract:BACKGROUND:Osteoarthritis is the most prevalent joint disease and a frequent cause of joint pain, functional loss, and disability. Osteoarthritis often becomes chronic, and conventional treatments have demonstrated only modest clinical benefits without lesion reversal. Cell-based therapies have shown encouraging result...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318291a2da
更新日期:2013-06-27 00:00:00
abstract:BACKGROUND:We explored the efficacy of the Oxford classification for assessing native immunoglobulin A nephropathy (IgAN) in posttransplantation patients compared with the glomerular injury score and Haas classification. METHODS:A total of 125 renal allograft biopsies obtained from 114 patients diagnosed with IgAN reg...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318291de65
更新日期:2013-06-27 00:00:00
abstract:BACKGROUND:Allogeneic bone marrow transplantation is under investigation for a range of nonmalignant indications, including tolerance induction through mixed chimerism. This strategy has so far been tested experimentally only in young recipients. Due to immunosenescence, older patients have an increase in memory T cell...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182954618
更新日期:2013-06-27 00:00:00
abstract:BACKGROUND:Ventricular assist devices (VADs) are increasingly being used in pediatric patients to provide long-term cardiac support. One potential complication of VAD therapy is the development of antibodies directed against human leukocyte antigens (HLA). This phenomenon has not been well described with the Berlin Hea...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182925242
更新日期:2013-06-27 00:00:00
abstract:BACKGROUND:At the time of transplantation, a recipient's serum is tested against the prospective donor's lymphocytes to identify specific reactivity and to look for a donor-specific crossmatch (CXM). Here, we investigated the relationship between the pretransplantation lymphocytotoxic CXM results and the long-term outc...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31828d155a
更新日期:2013-06-15 00:00:00
abstract:BACKGROUND:The prevalence of renal posttransplantation amputation and its impact on allograft and patient survival have not been widely reported. METHODS:We used an incident cohort of patients who underwent renal transplantation between June 2004 and September 2009. Amputation data were obtained using Medicare institu...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31828e72b4
更新日期:2013-05-27 00:00:00
abstract:BACKGROUND:U.S. allocation policies currently place less emphasis on human leukocyte antigen (HLA) matching in pediatric kidney transplant candidates to minimize dialysis time. The impact this may have on pediatric recipients after graft failure has not been extensively examined. METHODS:Using the Scientific Registry ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318288ca14
更新日期:2013-05-27 00:00:00
abstract:BACKGROUND:Peripancreatic fluid collections (PPFC) are a serious complication after simultaneous pancreas-kidney transplantation (SPKTx). METHODS:Retrospective study for all 223 SPKTx performed from December 8, 1996, to October 10, 2011, to evaluate the risk factors (RF) and impact of PPFCs on outcomes was conducted. ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318289c978
更新日期:2013-05-27 00:00:00
abstract:BACKGROUND:Human herpesvirus 6 (HHV-6) is susceptible to latency and reactivation in hematopoietic stem cell transplant (HSCT) recipients. We investigated the incidence of HHV-6 DNAemia and factors related to HHV-6 DNAemia and death after allogeneic stem cell transplantations. We also explored the relationship between ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318289958b
更新日期:2013-05-27 00:00:00
abstract:BACKGROUND:Kidney donation after cardiac death leads to vascular damage as a result of warm ischemia, affecting renovascular circulating volume. Novel ultrasound dilution techniques may be used to measure renovascular circulating volumes during hypothermic machine perfusion of donor kidneys. METHODS:Renovascular circu...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31828a46f7
更新日期:2013-05-15 00:00:00
abstract::Since 1989, the U.S. Food and Drug Administration (FDA) has encouraged the study of new drug and therapeutic products in elderly patients. However, despite the aging population in the United States, elderly patients continue to be underrepresented in clinical trials across a variety of therapeutic areas, including tra...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31828279d9
更新日期:2013-04-15 00:00:00
abstract::Pregnancy after solid organ transplantation, although considered high risk for maternal, fetal, and neonatal complications, has been quite successful. Tacrolimus pharmacokinetic changes during pregnancy make interpretation of whole blood trough concentrations particularly challenging. There are multiple factors that c...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0b013e318278d367
更新日期:2013-04-15 00:00:00
abstract:BACKGROUND:Human herpesvirus-6 (HHV-6) is known to reactivate after renal transplantation and has been associated with several clinical manifestations. Risk factors for sustained viral replication, however, remain unclear. METHODS:Thirty consecutive kidney transplant patients were prospectively followed for HHV-6 repl...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182807ab7
更新日期:2013-03-27 00:00:00
abstract::: Hepatitis C virus (HCV) infection is common in solid organ allograft recipients and is a significant cause of morbidity and mortality after transplantation, so effective management will improve outcomes. In this review, we discuss the extent of the problem associated with HCV infection in donors and kidney, heart, a...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0b013e318273fec4
更新日期:2013-03-27 00:00:00
abstract:BACKGROUND:Allogeneic hematopoietic stem cell transplantation is a potentially curative therapy for many malignant and nonmalignant hematologic diseases. However, acute graft-versus-host disease (aGVHD) is a lethal complication of hematopoietic stem cell transplantation, which limits its application. Cytokines such as ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31827e6b23
更新日期:2013-03-15 00:00:00
abstract:BACKGROUND:In the background of availability of better treatments for specific liver diseases and listing of nonalcoholic steatohepatitis (NASH) as an etiology for liver transplantation (LT), data are unclear on the impact of disease etiology on the frequency of LT and liver posttransplantation outcomes. METHODS:The U...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31827afb3a
更新日期:2013-03-15 00:00:00
abstract:BACKGROUND:Exercise training is effective in improving the cardiovascular risk profiles of nontransplanted patients, but the health benefits and potential harms of routine exercise training after solid organ transplantation are unclear. This study aims to assess the health benefits and harms of supervised exercise trai...
journal_title:Transplantation
pub_type: 杂志文章,meta分析,评审
doi:10.1097/TP.0b013e31827a3d3e
更新日期:2013-03-15 00:00:00
abstract::T cells must be activated before they can elicit damage to allografts, through interaction of their T cell receptor (TCR) with peptide-MHC complex and through accessory molecules. Signaling through accessory molecules or costimulatory molecules is a critical way for the immune system to fine tune T cell activation. An...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0b013e31826d4672
更新日期:2013-02-27 00:00:00
abstract:BACKGROUND:Long-term results of prospective randomized trials comparing triple immunosuppressive strategies combining tacrolimus (TAC) or cyclosporine A (CsA) with mycophenolate mofetil (MMF) and steroids after heart transplantation (HTX) are rarely published. Therefore, we collected long-term follow-up data of an inte...
journal_title:Transplantation
pub_type: 杂志文章,随机对照试验
doi:10.1097/TP.0b013e318277e378
更新日期:2013-02-27 00:00:00
abstract:BACKGROUND:Donation after cardiac death (DCD) increases the number of donor kidneys but is associated with more primary nonfunction (PNF) and delayed graft function (DGF). It has been suggested that biomarkers in the preservation solution of machine perfused kidneys may predict PNF, although evidence is lacking. METHO...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31827908e6
更新日期:2013-02-27 00:00:00
abstract::There is a striking consistency in the total number of heart beats accrued over a lifetime across a range of animal species despite vast differences in size. Moreover, an inverse relationship is observed between heart rate and lifespan, leading to speculation that elevated heart rate could significantly affect longevi...
journal_title:Transplantation
pub_type: 社论,评审
doi:10.1097/TP.0b013e31826bc42a
更新日期:2013-01-27 00:00:00
abstract:BACKGROUND:If pancreas transplantation is a validated alternative for type 1 diabetic patients with end-stage renal disease, the management of patients who have lost their primary graft is poorly defined. This study aims at evaluating pancreas retransplantation outcome. METHODS:Between 1976 and 2008, 569 pancreas tran...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/TP.0b013e318271d795
更新日期:2013-01-27 00:00:00
abstract:BACKGROUND:Intestinal allograft mucosa undergoes repopulation with host immunocytes. However, critical changes within key immunocyte subsets are not known. METHODS:To explain acute cellular rejection after intestine transplantation (ITx) on the basis of altered mucosal immunocytes, rejecting and rejection-free ITx all...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182708d9d
更新日期:2012-12-27 00:00:00
abstract:BACKGROUND:Currently, many transplantation centers do not follow former living kidney donors on a long-term basis. Several potential barriers have been identified to provide this follow-up of former living kidney donors, including concerns that donor insurance will not reimburse transplantation centers or primary care ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31826cc9a1
更新日期:2012-11-27 00:00:00
abstract:BACKGROUND:Umbilical cord blood transplantation (UCBT) is increasingly used and produces similar results to matched unrelated donor transplantation. METHODS:We performed a retrospective single-center analysis of 50 umbilical cord blood transplantations UCBTs performed from 2001 to 2010, including 37 single and 13 doub...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31826c39b2
更新日期:2012-11-27 00:00:00
abstract:BACKGROUND:Graft thrombosis immediately after surgery remains a problem for successful pancreas transplantation. The present study evaluated the efficacy of computed tomography (CT) angiography for monitoring of graft patency in the immediate postoperative period. METHODS:The study involved 119 patients who underwent ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182692b4d
更新日期:2012-11-15 00:00:00
abstract:BACKGROUND:The ability to induce tolerance, or at least minimize the need for immunosuppressive therapy, is a high priority in organ transplantation. Accomplishing this goal requires a novel method for determining when a patient has become tolerant to or is rejecting their graft. Here, we sought to develop an efficient...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182696a5b
更新日期:2012-10-27 00:00:00
abstract:BACKGROUND:Intestinal transplantation is known to be associated with a high risk of early complications and mortality. METHODS:We analyzed prospective data of 51 primary small bowel transplantations from December 1999 to August 2009 and identified perioperative factors that impact on early mortality (≤6 months after t...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318265c508
更新日期:2012-10-27 00:00:00
abstract:BACKGROUND:Selective inhibition of lymphocyte activation through abrogation of signal 3-cytokine transduction emerges as a new strategy for immunosuppression. This is the first report on the novel Janus kinase (JAK)1/3 inhibitors R507 and R545 for prevention of acute allograft rejection. METHODS:Pharmacokinetic and in...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182660496
更新日期:2012-10-15 00:00:00
abstract:BACKGROUND:The management of small bowel transplantation is unique because signs of rejection can be obtained visually by endoscopy. The aim of this study was to evaluate the accuracy of endoscopic appearance in assessing histologic evidence of acute cellular rejection (ACR). METHODS:Endoscopies were performed in 66 a...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31825f4410
更新日期:2012-10-15 00:00:00
abstract:BACKGROUND:Steroid-resistant acute rejection is a risk factor for inferior renal allograft outcome. METHODS:From 873 kidney transplant recipients (1995-2005), 108 patients with a first rejection episode were selected for study using strict inclusion criteria and clinical endpoint definition. We aimed to predict respon...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31825db651
更新日期:2012-09-27 00:00:00
abstract:BACKGROUND:Innate immunity plays a role in controlling adaptive immune responses. METHODS:We investigated the clinical relevance of single nucleotide polymorphisms in 22 genes encoding innate, secreted, and signaling pattern recognition receptors in a total of 520 donor-recipient pairs of postmortem, human leukocyte a...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31825c5967
更新日期:2012-09-15 00:00:00
abstract:BACKGROUND:A new supercooling system using a variable magnetic field has been recently developed. Subzero nonfreezing preservation has been believed to be a beneficial method because of the lower metabolic rate. The purpose of this study was to evaluate the hemodynamic and metabolic effects of rat heart preservation in...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182637054
更新日期:2012-09-15 00:00:00
abstract:BACKGROUND:ABO-incompatible organ transplantation typically induces hyperacute rejection. A2-to-O liver transplantations have been successful. This study compared overall and graft survival in O recipients of A2 and O grafts based on Organ Procurement and Transplantation Network data. METHODS:Scientific Registry of Tr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31825c591e
更新日期:2012-09-15 00:00:00
abstract:BACKGROUND:The role of anti-human leukocyte antigen (HLA) donor-specific antibodies (DSA) detected by Luminex in the development of rejection is not fully understood. METHODS:A study including 369 patients who received transplants from deceased donors with a negative complement-dependent cytotoxicity crossmatch (XM) w...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31825ace2c
更新日期:2012-08-27 00:00:00
abstract:BACKGROUND:The role of combined liver-kidney transplantation (CLKT) for cirrhotic patients with renal failure (RF) is controversial. Since the model for end-stage liver disease era, there has been a rise in the number of CLKT. Using the Organ Procurement Transplant Network/United Network for Organ Sharing database, thi...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182590d6b
更新日期:2012-08-27 00:00:00
abstract:BACKGROUND:Blood group-incompatible transplantation is one strategy used when a potential recipient does not have a compatible living donor. Current practice includes desensitization strategies to reduce antibody titers. However, when antibodies are low, in cardiac transplantation in neonates for example, no desensitiz...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31825b7608
更新日期:2012-08-27 00:00:00
abstract:BACKGROUND:Hemodynamic monitoring using transesophageal echocardiography (TEE) in patients with signs of portal hypertension undergoing orthotopic liver transplantation (OLT) carries potential risk of esophageal and gastric variceal hemorrhage. The aim of our retrospective analysis was to evaluate the safety of intraop...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31825475c2
更新日期:2012-07-27 00:00:00
abstract:BACKGROUND:Renal ischemia-reperfusion (I/R) injury is unavoidable in kidney transplantation and frequently influences both short- and long-term allograft survival rates. One of the major events in I/R injury is the generation of cytotoxic oxygen radicals. Recently, hydrogen gas has been reported to display antioxidant ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318255f8be
更新日期:2012-07-15 00:00:00